One Injection Reverses Diabetes Symptoms Without Side Effects

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One Injection Reverses Diabetes Symptoms Without Side Effects
Too much sugar in the bloodstream is equivalent to a car in the danger zone. The growth factor FGF1 has been shown to bring glucose levels back to normal / Salk Institute for Biological Studies

There’s no cure for type 2 diabetes right now, and even with the best practices and therapies, healthy glucose levels are hard to achieve. Now researchers say they're onto a potential treatment that can restore normal insulin activity, normalizing blood sugar levels with just one injection. So far it works without adverse side effects, at least in mice.

With type 1 diabetes, the body attacks the cells that produce the glucose-lowering hormone insulin, which is needed to keep sugar levels from building up in the blood. People with type 2 diabetes can produce insulin, but the body doesn’t respond to it properly and ends up resisting its effects -- this is called insulin resistance or insensitivity. At first, the pancreas keeps up by making more insulin, but over time, the pancreas just stops making enough. A group of drugs called thiazolidinediones can restore normal responses to insulin, but they come with side effects ranging from bone loss to accumulation of fat in the liver.

So, a large international team led by Michael Downes and Ronald Evans from the Salk Institute for Biological Studies investigated a promising protein called fibroblast growth factor 1 (FGF1). Previous work has suggested that FGF1 helps regulate insulin sensitivity: Mice who lack the factor quickly developed diabetes when fed a high-fat diet.

In this study, the researchers injected the protein into the bloodstream of diabetic mice and found a potent, glucose lowering effect -- without weight gain, bone loss, or fatty buildup in the liver. The work was published in Nature this week.

A single dose was enough to restore blood sugar levels to a healthy range for several days. Sustained treatment, with repeated injections over a month, reversed insulin resistance, restoring the body’s own ability to regulate blood sugar levels. And even at those higher doses, FGF1 didn’t trigger detrimental side effects or cause glucose levels to drop precipitously.

Furthermore, injecting FGF1 in healthy mice had no apparent effect, nor did it work in mice who don’t produce insulin at all (such as with type 1 diabetes). That means FGF1 specifically works with and through insulin to lower glucose levels in diabetes, the Conversation explains.

Pictured below, fat-filled cells (small white, A) are prolific in the liver tissue of obese animals with type 2 diabetes. After repeated FGF1 injections, the liver cells successfully lose fat and absorb sugar from the bloodstream (small purple, B) and more closely resemble cells of non-diabetic animals.

One Injection Reverses Diabetes Symptoms Without Side Effects
Salk Institute for Biological Studies

The findings are still preliminary, and the team needs to figure out how FGF1 exerts its beneficial effects. But if they can suss that out and show that it can work in humans, the protein has huge therapeutic potential for many metabolic diseases characterized by insulin resistance. "Controlling glucose is a dominant problem in our society," Evans says in a news release. "And FGF1 offers a new method to control glucose in a powerful and unexpected way."

Source: IFL Science

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  1. five months ago I constantly had to go to the bathroom. I thought it was because I gave up soft drinks and was only drinking water. One day I had a stomachache. I was in bed for 4 days. The doctor's appointment was for a Wednesday. I got sick and went to emergency room on a Monday. I was told my blood sugar level was 810 and I have diabetes. Since then, As the disease progressed all medication stopped working, i was introduced to Health herbal clinic in Johannesburg who have successful herbal treatment to diabetes . I spoke to few people who used the treatment here in USA and they all gave a positive response, so i immediately purchased the diabetes herbal remedy and commenced usage, i used the herbal supplement for only 7 weeks, all symptoms gradually faded away, herbs are truly gift from God. contact this herbal clinic via their email healthherbalclinic @ gmail. com or visit www. healthherbalclinic. weebly. com

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Thinking Humanity: One Injection Reverses Diabetes Symptoms Without Side Effects
One Injection Reverses Diabetes Symptoms Without Side Effects
There’s no cure for type 2 diabetes right now, and even with the best practices and therapies, healthy glucose levels are hard to achieve. Now researchers say they're onto a potential treatment that can restore normal insulin activity, normalizing blood sugar levels with just one injection.
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