Scientists Cure Diabetes In Mice With No Side Effects

Scientists Cure Diabetes In Mice With No Side Effects

A potential cure for Type 1 diabetes appeared on the horizon in San Antonio. The novel approach would also allow people who suffer from Type 2 diabetes to quit insulin shots.

Researchers at The University of Texas Health Science Center, which is now called UT Health San Antonio, made a discovery that increases the types of pancreatic cells that secrete insulin.

UT Health San Antonio researchers aim to reach human clinical trials in 3 years. However, to do so they should first test their strategy in large-animal studies, that will cost approximately $5 million.

These studies will foreshadow application to the U.S. Food and Drug Administration for Investigational New Drug (IND) approval, as Bruno Doiron, Ph.D., a co-inventor, stated.

The researchers received a U.S. patent in January, and UT Health San Antonio is spinning out a company to start commercialization.

Their strategy has cured diabetes in mice.

According to Dr. Doiron, assistant professor of medicine at UT Health, the strategy "worked perfectly. We cured mice for one year without any side effects. That's never been seen. But it's a mouse model, so caution is needed. We want to bring this to large animals that are closer to humans in physiology of the endocrine system."

As Ralph DeFronzo, M.D., professor of medicine and chief of the Division of Diabetes at UT Health, and co-inventor on the patent described the therapy:

"The pancreas has many other cell types besides beta cells, and our approach is to alter these cells so that they start to secrete insulin, but only in response to glucose [sugar]. This is basically just like beta cells."

Insulin, which reduces blood sugar, is only created by beta cells. Here's what happens in Type 1 diabetes: beta cells are destroyed by the immune system and, then, the person has no insulin. In Type 2 diabetes, beta cells fail, and insulin is lowered. At the same time in Type 2, the body doesn't use insulin in an efficient way.

The therapy is accomplished by a technique named gene transfer. A virus is used as a vector, or carrier, in order to introduce selected genes into the pancreas. The genes become incorporated and cause digestive enzymes and other cell types to make insulin.

Gene transfer using a viral vector has been approved approximately 50 times by the U.S. Food & Drug Administration to cure various diseases, Dr. DeFronzo noted. It is proven in curing rare childhood diseases, and Good Manufacturing Processes guarantee safety.

Contrary to beta cells, which the body rejects in Type 1 diabetes, the rest of cell populations of the pancreas co-exist with the body's immune defenses.

As Dr. DeFronzo said:

"If a Type 1 diabetic has been living with these cells for 30, 40 or 50 years, and all we're getting them to do is secrete insulin, we expect there to be no adverse immune response."

The second-by-second sugar control precisely regulates blood sugar in mice. This could be a great advance over traditional insulin therapy and some diabetes medications which drop blood sugar very low unless they are closely monitored.

"A major problem we have in the field of Type 1 diabetes is hypoglycemia (low blood sugar)," Dr. Doiron said. "The gene transfer we propose is remarkable because the altered cells match the characteristics of beta cells. Insulin is only released in response to glucose."

Provided by: University of Texas Health Science Center at San Antonio

Reference: Medical Express
Scientists Cure Diabetes In Mice With No Side Effects Scientists Cure Diabetes In Mice With No Side Effects Reviewed by Κατερίνα Παπ on 3:30 PM Rating: 5

6 comments

  1. So excited for Daredevil season 3. I just wish they would hurry up and bring out the season as fast as possible especially because they left the last season with so many unanswered questions.
    Really hyped to see Charlie Cox as Matt Murdock and Deborah Ann Woll as Karen Page. For more details please visit Gamersden

    ReplyDelete
    Replies
    1. QUICK CURE OF HERPES SIMPLEX VIRUS 1 & 2 WITH { [email protected] }

      I will advice you to contact Dr Oshogum([email protected] ) who solve all problems and give cure very fast without stress and delay. i was getting drawn in herpes virus, and medical prescription (Aciclovir‎, ‎valaciclovir‎, ‎Valtrex‎... etc) was not helping me. Till a lab doctor (my friend) direct me to contact Dr oshogum for quick cure because he also read from people whom Dr oshogum have cure of HSV 1 & 2; Virus, HIV/AID, HLS virus, Hepatitis B, STAGE 3 cancer and other STD's. I contact him as direct with his email, i explain my problem to him. He replied with what he want me to do as soon as possible because he don't want delay. After i did what he ask, he send me a Remedy which i used as he prescribed. He is a miracle worker.. It is never too late with Dr oshogum contact him today with { [email protected] }. I went for test after two week and my result came out negative. Today again i did text and my result is always negative. Note he also have cures to diseases like

      PENIS ENLARGEMENT
      ANAL FISSURE VIRUS
      DIABETES 1/2
      WEAK ERECTION
      HERPES
      HIV/AIDS
      PILE
      STROKE
      PREMATURE EJACULATION
      ERECTILE DYSFUNCTION
      HPV
      ALS
      CANCER/RECTUM OR PROSTRATE
      HEART FAILURE

      Delete
  2. Your article reflects the issue people are concerned about. The article provides timely information that reflects multi-dimensional views from multiple perspectives. I look forward to reading quality articles that contain timely information from you.
    html color

    ReplyDelete
  3. Thanks for your post! Through your pen I found the problem up interesting! I believe there are many other people who are interested in them just like me! How long does it take to complete this article? I have read through other blogs, but they are cumbersome and confusing. I hope you continue to have such quality articles to share with everyone!
    vex 3

    ReplyDelete
  4. Expectations are high regarding the new features which are going to come in with the launch of FIFA 18.
    And particularly after an exhilarating release of the trailer a few days back, fans have gone really crazy.
    A high-quality game is definitely on the cards. Want to know more about it? Check out this website Gamegoal

    ReplyDelete
  5. UT Health San Antonio analysts plan to achieve human clinical trials in 3 years. Dissertation Notwithstanding, to do as such they should first test their technique in vast creature ponders, that will cost around $5 million.

    ReplyDelete

Don't show again. Close

Like us on Facebook?